[Bis(2-pyridyldimethylsilyl)methyl]lithium. New Reagent for the Stereoselective Synthesis of Vinylsilanes

[Bis(2-pyridyldimethylsilyl)methyl]lithium. New Reagent for the Stereoselective Synthesis of Vinylsilanes

The generation of (2-PyMe2Si)2CHLi was easily accomplished by the deprotonation of (2-PyMe2Si)2CH2 using n-BuLi in Et2O. Thus generated (2-PyMe2Si)2CHLi was found to react with a variety of aldehydes and ketones to give the corresponding vinylsilanes in extremely high yields with complete stereosele...

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Veröffentlicht in:Organic letters 2000-05, Vol.2 (9), p.1299-1302
Hauptverfasser: Itami, Kenichiro, Nokami, Toshiki, Yoshida, Jun-ichi
Format: Artikel
Sprache:eng
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Zusammenfassung:The generation of (2-PyMe2Si)2CHLi was easily accomplished by the deprotonation of (2-PyMe2Si)2CH2 using n-BuLi in Et2O. Thus generated (2-PyMe2Si)2CHLi was found to react with a variety of aldehydes and ketones to give the corresponding vinylsilanes in extremely high yields with complete stereoselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol005735n