Chemistry of Sponges. 19. Novel Bioactive Metabolites from Hamigera t arangaensis

Chemistry of Sponges. 19. Novel Bioactive Metabolites from Hamigera t arangaensis

Seven new compounds (1−6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3−6 showed moderat...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2000-01, Vol.63 (1), p.79-85
Hauptverfasser: Wellington, Keri D, Cambie, Richard C, Rutledge, Peter S, Bergquist, Patricia R
Format: Artikel
Sprache:eng
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Zusammenfassung:Seven new compounds (1−6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3−6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9903494