Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens

Activity-guided fractionation of the leaves of Aloe arborescens resulted in the isolation and characterization of the known compounds elgonica-dimers A (1) and B (2) as potent inhibitors of cytosolic alcohol dehydrogenase and aldehyde dehydrogenase activities in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-11, Vol.60 (11), p.1180-1182
Hauptverfasser:	Shin, Kuk Hyun, Woo, Won Sick, Lim, Soon Sung, Shim, Chang Sub, Chung, Ha Sook, Kennelly, Edward J, Kinghorn, A. Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	ALCOHOL DEHYDROGENASE ALCOHOL DESHIDROGENASA ALCOHOLES ALCOHOLS ALCOOL ALCOOL DESHYDROGENASE ALDEHYDE DEHYDROGENASE ALOE ALOE-EMODIN ALOENIN Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE CHROMONES CITOPLASMA COMPOSICION QUIMICA COMPOSITION CHIMIQUE CULTIVO IN VITRO CULTURE IN VITRO CYTOPLASM CYTOPLASME CYTOSOL DERIVATIVES EMODIN ENZYME INHIBITORS ESPECTROMETRIA ESTRUCTURA QUIMICA ETHYLIDENE-ALOENIN FEUILLE General pharmacology HOJAS IN VITRO CULTURE INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME LEAVES Medical sciences METABOLISM METABOLISME METABOLISMO MICOTOXINAS MYCOTOXINE MYCOTOXINS OXIDOREDUCTASES OXIDORREDUCTASAS OXYDOREDUCTASE Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PIGMENT PIGMENTOS PIGMENTS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE
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Beschreibung
Zusammenfassung:	Activity-guided fractionation of the leaves of Aloe arborescens resulted in the isolation and characterization of the known compounds elgonica-dimers A (1) and B (2) as potent inhibitors of cytosolic alcohol dehydrogenase and aldehyde dehydrogenase activities in vitro.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9703104