Microbiological Hydroxylation at Eight Individual Carbon Atoms of Marcfortine A

Hydroxylation of the indole alkaloid marcfortine A (1) at carbon atoms 5, 10, 12, 14, 15, 16, and 27 was realized by various soil-derived microorganisms. Fission at the C-12−N bond was also observed. The structural elucidation of the products (2 − 12) was accomplished by spectroscopic and semisynthe...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-11, Vol.60 (11), p.1139-1142
Hauptverfasser:	Lee, Byung H, Kornis, Gabe I, Cialdella, Joyce I, Clothier, Michael F, Marshall, Vincent P, Martin, David G, McNally, Patty L, Mizsak, Stephen A, Whaley, Howard A, Wiley, Veronica H
Format:	Artikel
Sprache:	eng
Schlagworte:	ALCALOIDE ALCALOIDES ALKALOIDS ANTHELMINTHIQUE ANTHELMINTICS Antibiotics. Antiinfectious agents. Antiparasitic agents ANTIHELMINTICOS Antiparasitic agents BACTERIA Bioconversions. Hemisynthesis BIODEGRADACION BIODEGRADATION Biological and medical sciences Biotechnology CHAMPIGNON DU SOL CHEMICAL COMPOSITION CHEMICAL REACTIONS CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE CONTROL DE ENFERMEDADES CONTROLE DE MALADIES DIGESTIVE SYSTEM DISEASES DISEASE CONTROL ENFERMEDADES DEL SISTEMA DIGESTIVO ESPECTROMETRIA ESTRUCTURA QUIMICA FLORA DEL SUELO FLORE DU SOL Fundamental and applied biological sciences. Psychology GASTROINTESTINAL DISEASES HONGOS DEL SUELO INDOL INDOLES MALADIE DE L'APPAREIL DIGESTIF Medical sciences METABOLITE METABOLITES METABOLITOS Methods. Procedures. Technologies MICROBIAL DEGRADATION NEMATODA PARAHERQUAMIDE A PARASITE PARASITES PARASITOS PENICILLIUM ROQUEFORTI Pharmacology. Drug treatments REACCIONES QUIMICAS REACTION CHIMIQUE SOIL FLORA SOIL FUNGI SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE SYNTHESIS
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Zusammenfassung:	Hydroxylation of the indole alkaloid marcfortine A (1) at carbon atoms 5, 10, 12, 14, 15, 16, and 27 was realized by various soil-derived microorganisms. Fission at the C-12−N bond was also observed. The structural elucidation of the products (2 − 12) was accomplished by spectroscopic and semisynthetic means.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9702805