Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme
As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH−CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretatio...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1997-03, Vol.60 (3), p.306-308 |
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| container_end_page | 308 |
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| container_issue | 3 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 60 |
| creator | Patil, Ashok D Freyer, Alan J Eggleston, Drake S Haltiwanger, R. Curtis Tomcowicz, Brian Breen, Ann Johnson, Randall K |
| description | As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH−CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretation of spectral data and X-ray analysis. Daleformis (1) inhibited ECE with an IC50 of 9 μM. |
| doi_str_mv | 10.1021/np960654e |
| format | Article |
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Daleformis (1) inhibited ECE with an IC50 of 9 μM.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np960654e</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; CHEMICAL COMPOSITION ; CHEMICAL STRUCTURE ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; DRUG PLANTS ; ENZYME INHIBITORS ; EPITELIO ; EPITHELIUM ; ESPECTROMETRIA ; ESTRUCTURA QUIMICA ; FABACEAE ; FITOALEXINA ; General pharmacology ; HIPERTENSION ARTERIAL ; HYPERTENSION ; INHIBIDORES DE ENZIMAS ; INHIBITEUR D'ENZYME ; LEGUMINOSAE ; Medical sciences ; MEXICO ; MEXIQUE ; PEPTIDASAS ; PEPTIDASE ; PEPTIDASES ; PHARMACEUTICAL PRODUCTS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; PHYTOALEXINE ; PHYTOALEXINS ; PLANTAS MEDICINALES ; PLANTE MEDICINALE ; RACINE ; RAICES ; ROOTS ; SPECTRAL ANALYSIS ; SPECTROMETRIE ; SPECTROMETRY ; STRUCTURE CHIMIQUE</subject><ispartof>Journal of natural products (Washington, D.C.), 1997-03, Vol.60 (3), p.306-308</ispartof><rights>Copyright © 1997 American Chemical Society and American Society of Pharmacognosy</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a379t-3aa878e57dbf69658e85e31e6d72712d2703eddf2cfbffeea8c3aa5a4f2cdd173</citedby><cites>FETCH-LOGICAL-a379t-3aa878e57dbf69658e85e31e6d72712d2703eddf2cfbffeea8c3aa5a4f2cdd173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np960654e$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np960654e$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2635235$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Patil, Ashok D</creatorcontrib><creatorcontrib>Freyer, Alan J</creatorcontrib><creatorcontrib>Eggleston, Drake S</creatorcontrib><creatorcontrib>Haltiwanger, R. Curtis</creatorcontrib><creatorcontrib>Tomcowicz, Brian</creatorcontrib><creatorcontrib>Breen, Ann</creatorcontrib><creatorcontrib>Johnson, Randall K</creatorcontrib><title>Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH−CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretation of spectral data and X-ray analysis. Daleformis (1) inhibited ECE with an IC50 of 9 μM.</description><subject>Biological and medical sciences</subject><subject>CHEMICAL COMPOSITION</subject><subject>CHEMICAL STRUCTURE</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>DRUG PLANTS</subject><subject>ENZYME INHIBITORS</subject><subject>EPITELIO</subject><subject>EPITHELIUM</subject><subject>ESPECTROMETRIA</subject><subject>ESTRUCTURA QUIMICA</subject><subject>FABACEAE</subject><subject>FITOALEXINA</subject><subject>General pharmacology</subject><subject>HIPERTENSION ARTERIAL</subject><subject>HYPERTENSION</subject><subject>INHIBIDORES DE ENZIMAS</subject><subject>INHIBITEUR D'ENZYME</subject><subject>LEGUMINOSAE</subject><subject>Medical sciences</subject><subject>MEXICO</subject><subject>MEXIQUE</subject><subject>PEPTIDASAS</subject><subject>PEPTIDASE</subject><subject>PEPTIDASES</subject><subject>PHARMACEUTICAL PRODUCTS</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Curtis</creator><creator>Tomcowicz, Brian</creator><creator>Breen, Ann</creator><creator>Johnson, Randall K</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19970301</creationdate><title>Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme</title><author>Patil, Ashok D ; Freyer, Alan J ; Eggleston, Drake S ; Haltiwanger, R. 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| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1997-03, Vol.60 (3), p.306-308 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_np960654e |
| source | American Chemical Society Journals |
| subjects | Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE DRUG PLANTS ENZYME INHIBITORS EPITELIO EPITHELIUM ESPECTROMETRIA ESTRUCTURA QUIMICA FABACEAE FITOALEXINA General pharmacology HIPERTENSION ARTERIAL HYPERTENSION INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME LEGUMINOSAE Medical sciences MEXICO MEXIQUE PEPTIDASAS PEPTIDASE PEPTIDASES PHARMACEUTICAL PRODUCTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PHYTOALEXINE PHYTOALEXINS PLANTAS MEDICINALES PLANTE MEDICINALE RACINE RAICES ROOTS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE |
| title | Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme |
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