Daleformis, a New Phytoalexin from the Roots of Dalea filiciformis: An Inhibitor of Endothelin Converting Enzyme

As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH−CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretatio...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-03, Vol.60 (3), p.306-308
Hauptverfasser:	Patil, Ashok D, Freyer, Alan J, Eggleston, Drake S, Haltiwanger, R. Curtis, Tomcowicz, Brian, Breen, Ann, Johnson, Randall K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE DRUG PLANTS ENZYME INHIBITORS EPITELIO EPITHELIUM ESPECTROMETRIA ESTRUCTURA QUIMICA FABACEAE FITOALEXINA General pharmacology HIPERTENSION ARTERIAL HYPERTENSION INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME LEGUMINOSAE Medical sciences MEXICO MEXIQUE PEPTIDASAS PEPTIDASE PEPTIDASES PHARMACEUTICAL PRODUCTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PHYTOALEXINE PHYTOALEXINS PLANTAS MEDICINALES PLANTE MEDICINALE RACINE RAICES ROOTS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE
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Beschreibung
Zusammenfassung:	As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH−CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active. Bioassay-guided fractionation of the extract yielded a novel phytoalexin, daleformis (1), whose structure was determined by interpretation of spectral data and X-ray analysis. Daleformis (1) inhibited ECE with an IC50 of 9 μM.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np960654e