Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa
An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretati...
Gespeichert in:
| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2010-02, Vol.73 (2), p.104-108 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 108 |
|---|---|
| container_issue | 2 |
| container_start_page | 104 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 73 |
| creator | Xu, Gang Kan, Winnie L. T Zhou, Yan Song, Jing-Zheng Han, Quan-Bin Qiao, Chun-Feng Cho, Chi-Hin Rudd, John A Lin, Ge Xu, Hong-Xi |
| description | An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells. |
| doi_str_mv | 10.1021/np9004147 |
| format | Article |
| fullrecord | <record><control><sourceid>acs_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1021_np9004147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>b411714945</sourcerecordid><originalsourceid>FETCH-LOGICAL-a344t-c3cb60bcb662ad9f028337a9e288132f61ebb5490759eab147c40b2c4b49f8b23</originalsourceid><addsrcrecordid>eNpt0E1PAjEQBuDGaATRg3_A9OLBw-r0Y5ftkaCCCYkXPG_a0kLJst20C7j_3jUgXLzMXJ7MzDsI3RN4JkDJS1ULAE748AL1SUohyYCml6gPJGMJyzPeQzcxrgGAgUivUY8CpLlgrI-m47bxjf92Go90W9ar0ge_LLfaVb7Erya4nWzczkRsg9_gZmXwfO-WEXuLJzJ0zEms_V7eoisry2jujn2Avt7f5uNpMvucfIxHs0QyzptEM60yUF3JqFwICzRnbCiFoXlOGLUZMUqlXMAwFUaqLpPmoKjmigubK8oG6OkwVwcfYzC2qIPbyNAWBIrfbxSnb3T24WDrrdqYxUn-xe_A4xHIqGVpg6y0i2dHU8q7Q85O6lis_TZUXcR_Fv4A3Wtyrg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa</title><source>MEDLINE</source><source>ACS Publications</source><creator>Xu, Gang ; Kan, Winnie L. T ; Zhou, Yan ; Song, Jing-Zheng ; Han, Quan-Bin ; Qiao, Chun-Feng ; Cho, Chi-Hin ; Rudd, John A ; Lin, Ge ; Xu, Hong-Xi</creator><creatorcontrib>Xu, Gang ; Kan, Winnie L. T ; Zhou, Yan ; Song, Jing-Zheng ; Han, Quan-Bin ; Qiao, Chun-Feng ; Cho, Chi-Hin ; Rudd, John A ; Lin, Ge ; Xu, Hong-Xi</creatorcontrib><description>An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np9004147</identifier><identifier>PMID: 20058933</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Drug Screening Assays, Antitumor ; Drugs, Chinese Herbal - pharmacology ; Garcinia - chemistry ; General pharmacology ; HCT116 Cells ; HT29 Cells ; Humans ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phloroglucinol - analogs & derivatives ; Phloroglucinol - chemistry ; Phloroglucinol - isolation & purification ; Phloroglucinol - pharmacology ; Plant Stems - chemistry ; Plants, Medicinal - chemistry</subject><ispartof>Journal of natural products (Washington, D.C.), 2010-02, Vol.73 (2), p.104-108</ispartof><rights>Copyright © 2010 American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a344t-c3cb60bcb662ad9f028337a9e288132f61ebb5490759eab147c40b2c4b49f8b23</citedby><cites>FETCH-LOGICAL-a344t-c3cb60bcb662ad9f028337a9e288132f61ebb5490759eab147c40b2c4b49f8b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np9004147$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np9004147$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22524759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20058933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Gang</creatorcontrib><creatorcontrib>Kan, Winnie L. T</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Song, Jing-Zheng</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Qiao, Chun-Feng</creatorcontrib><creatorcontrib>Cho, Chi-Hin</creatorcontrib><creatorcontrib>Rudd, John A</creatorcontrib><creatorcontrib>Lin, Ge</creatorcontrib><creatorcontrib>Xu, Hong-Xi</creatorcontrib><title>Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Garcinia - chemistry</subject><subject>General pharmacology</subject><subject>HCT116 Cells</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phloroglucinol - analogs & derivatives</subject><subject>Phloroglucinol - chemistry</subject><subject>Phloroglucinol - isolation & purification</subject><subject>Phloroglucinol - pharmacology</subject><subject>Plant Stems - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1PAjEQBuDGaATRg3_A9OLBw-r0Y5ftkaCCCYkXPG_a0kLJst20C7j_3jUgXLzMXJ7MzDsI3RN4JkDJS1ULAE748AL1SUohyYCml6gPJGMJyzPeQzcxrgGAgUivUY8CpLlgrI-m47bxjf92Go90W9ar0ge_LLfaVb7Erya4nWzczkRsg9_gZmXwfO-WEXuLJzJ0zEms_V7eoisry2jujn2Avt7f5uNpMvucfIxHs0QyzptEM60yUF3JqFwICzRnbCiFoXlOGLUZMUqlXMAwFUaqLpPmoKjmigubK8oG6OkwVwcfYzC2qIPbyNAWBIrfbxSnb3T24WDrrdqYxUn-xe_A4xHIqGVpg6y0i2dHU8q7Q85O6lis_TZUXcR_Fv4A3Wtyrg</recordid><startdate>20100226</startdate><enddate>20100226</enddate><creator>Xu, Gang</creator><creator>Kan, Winnie L. T</creator><creator>Zhou, Yan</creator><creator>Song, Jing-Zheng</creator><creator>Han, Quan-Bin</creator><creator>Qiao, Chun-Feng</creator><creator>Cho, Chi-Hin</creator><creator>Rudd, John A</creator><creator>Lin, Ge</creator><creator>Xu, Hong-Xi</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20100226</creationdate><title>Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa</title><author>Xu, Gang ; Kan, Winnie L. T ; Zhou, Yan ; Song, Jing-Zheng ; Han, Quan-Bin ; Qiao, Chun-Feng ; Cho, Chi-Hin ; Rudd, John A ; Lin, Ge ; Xu, Hong-Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a344t-c3cb60bcb662ad9f028337a9e288132f61ebb5490759eab147c40b2c4b49f8b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Garcinia - chemistry</topic><topic>General pharmacology</topic><topic>HCT116 Cells</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phloroglucinol - analogs & derivatives</topic><topic>Phloroglucinol - chemistry</topic><topic>Phloroglucinol - isolation & purification</topic><topic>Phloroglucinol - pharmacology</topic><topic>Plant Stems - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Gang</creatorcontrib><creatorcontrib>Kan, Winnie L. T</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Song, Jing-Zheng</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Qiao, Chun-Feng</creatorcontrib><creatorcontrib>Cho, Chi-Hin</creatorcontrib><creatorcontrib>Rudd, John A</creatorcontrib><creatorcontrib>Lin, Ge</creatorcontrib><creatorcontrib>Xu, Hong-Xi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Gang</au><au>Kan, Winnie L. T</au><au>Zhou, Yan</au><au>Song, Jing-Zheng</au><au>Han, Quan-Bin</au><au>Qiao, Chun-Feng</au><au>Cho, Chi-Hin</au><au>Rudd, John A</au><au>Lin, Ge</au><au>Xu, Hong-Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2010-02-26</date><risdate>2010</risdate><volume>73</volume><issue>2</issue><spage>104</spage><epage>108</epage><pages>104-108</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.</abstract><cop>Northbrook, IL</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>20058933</pmid><doi>10.1021/np9004147</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2010-02, Vol.73 (2), p.104-108 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_np9004147 |
| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor Drugs, Chinese Herbal - pharmacology Garcinia - chemistry General pharmacology HCT116 Cells HT29 Cells Humans Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology Plant Stems - chemistry Plants, Medicinal - chemistry |
| title | Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T05%3A50%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-acs_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytotoxic%20Acylphloroglucinol%20Derivatives%20from%20the%20Twigs%20of%20Garcinia%20cowa&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Xu,%20Gang&rft.date=2010-02-26&rft.volume=73&rft.issue=2&rft.spage=104&rft.epage=108&rft.pages=104-108&rft.issn=0163-3864&rft.eissn=1520-6025&rft.coden=JNPRDF&rft_id=info:doi/10.1021/np9004147&rft_dat=%3Cacs_cross%3Eb411714945%3C/acs_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/20058933&rfr_iscdi=true |