Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa

An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretati...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2010-02, Vol.73 (2), p.104-108
Hauptverfasser: Xu, Gang, Kan, Winnie L. T, Zhou, Yan, Song, Jing-Zheng, Han, Quan-Bin, Qiao, Chun-Feng, Cho, Chi-Hin, Rudd, John A, Lin, Ge, Xu, Hong-Xi
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Sprache:eng
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Zusammenfassung:An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1−4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9004147