Jerantinines A−G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa

Seven new indole alkaloids of the Aspidosperma type, jerantinines A−G (1−7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1−5, 8, 9) displayed pronounced in v...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-09, Vol.71 (9), p.1591-1594
Hauptverfasser:	Lim, Kuan-Hon, Hiraku, Osamu, Komiyama, Kanki, Kam, Toh-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Aspidosperma Biological and medical sciences chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor General pharmacology Humans indole alkaloids Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology jerantinine KB Cells Malaysia Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry spectral analysis Tabernaemontana Tabernaemontana - chemistry Tabernaemontana corymbosa
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Zusammenfassung:	Seven new indole alkaloids of the Aspidosperma type, jerantinines A−G (1−7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1−5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 μg/mL).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np800435c