Anti-Tumor-Promoting Activities of Afromosin and Soyasaponin I Isolated from Wistaria brachybotrys

Afromosin [1] and soyasaponin I [2] isolated from Wistaria brachybotrys exhibited remarkable inhibitory effects on mouse skin tumor promotion, and afromosin also exhibited a significant inhibitory effect on pulmonary tumor promotion. The combined effects of these compounds on the two-stage skin carc...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1992-12, Vol.55 (12), p.1776-1778
Hauptverfasser:	Konoshima, Takao, Kokumai, Midori, Kozuka, Mutsuo, Tokuda, Harukuni, Nishino, Hoyoku, Iwahima, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology Biological and medical sciences Cocarcinogenesis Female General pharmacology Isoflavones - isolation & purification Isoflavones - pharmacology Lung Neoplasms - chemically induced Lung Neoplasms - prevention & control Medical sciences Mice Mice, Inbred ICR Oleanolic Acid - analogs & derivatives Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Saponins - isolation & purification Saponins - pharmacology Skin Neoplasms - chemically induced Skin Neoplasms - prevention & control Tetradecanoylphorbol Acetate - toxicity
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Zusammenfassung:	Afromosin [1] and soyasaponin I [2] isolated from Wistaria brachybotrys exhibited remarkable inhibitory effects on mouse skin tumor promotion, and afromosin also exhibited a significant inhibitory effect on pulmonary tumor promotion. The combined effects of these compounds on the two-stage skin carcinogenesis were also examined, and it was concluded that the combination of 1 with 2 enhanced the inhibitory effect.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50090a011