UV-Mediated Genotoxicity of Furanoquinoline and of Certain Tryptophan-Derived Alkaloids
Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and t...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1983-07, Vol.46 (4), p.576-581 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Towers, G. H. N Abramowski, Z |
| description | Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and the N-methylpyrolidine substituted harmane alkaloid, brevicolline (from Carex), display phototoxicity towards bacteria and fungi in near ultraviolet light. All of these alkaloids are phototoxic to Chinese hamster ovary cells, inhibiting mitosis and causing gross chromosomal changes. The target for their phototoxicity appears to be the cell nucleus. |
| doi_str_mv | 10.1021/np50028a027 |
| format | Article |
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H. N ; Abramowski, Z</creator><creatorcontrib>Towers, G. H. N ; Abramowski, Z ; Tsentralen S"vet na Natsionalniya Agrarno-Promishlen S"yuz, Sofia (Bulgaria). Selskostopanska Akademiya. T"rgovsko-Promishleno Obedinenie "Bulgartabak</creatorcontrib><description>Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and the N-methylpyrolidine substituted harmane alkaloid, brevicolline (from Carex), display phototoxicity towards bacteria and fungi in near ultraviolet light. All of these alkaloids are phototoxic to Chinese hamster ovary cells, inhibiting mitosis and causing gross chromosomal changes. The target for their phototoxicity appears to be the cell nucleus.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np50028a027</identifier><identifier>PMID: 6195312</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Alkaloids - toxicity ; Animals ; Biological and medical sciences ; Carex ; Cells, Cultured ; Chromosome Aberrations ; Cricetinae ; Cricetulus ; DNA - analysis ; Female ; Furans - toxicity ; General pharmacology ; Genes - drug effects ; Medical sciences ; Ovary ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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H. N</creatorcontrib><creatorcontrib>Abramowski, Z</creatorcontrib><creatorcontrib>Tsentralen S"vet na Natsionalniya Agrarno-Promishlen S"yuz, Sofia (Bulgaria). Selskostopanska Akademiya. T"rgovsko-Promishleno Obedinenie "Bulgartabak</creatorcontrib><title>UV-Mediated Genotoxicity of Furanoquinoline and of Certain Tryptophan-Derived Alkaloids</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and the N-methylpyrolidine substituted harmane alkaloid, brevicolline (from Carex), display phototoxicity towards bacteria and fungi in near ultraviolet light. All of these alkaloids are phototoxic to Chinese hamster ovary cells, inhibiting mitosis and causing gross chromosomal changes. The target for their phototoxicity appears to be the cell nucleus.</description><subject>Alkaloids - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carex</subject><subject>Cells, Cultured</subject><subject>Chromosome Aberrations</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>DNA - analysis</subject><subject>Female</subject><subject>Furans - toxicity</subject><subject>General pharmacology</subject><subject>Genes - drug effects</subject><subject>Medical sciences</subject><subject>Ovary</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinolines - toxicity</subject><subject>RNA - analysis</subject><subject>Rutaceae</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1v1DAQBmALgcpSOHEGckDigAJjO3biY7WwBanlQ92FozVJbHCb2sHOou6_x6usVkhwsjTz6JXnJeQphTcUGH3rRwHAGgRW3yMLKhiUEpi4TxZAJS95I6uH5FFK1wDAQYkTciKpEpyyBfm--VZemt7hZPri3PgwhTvXuWlXBFusthF9-LV1PgzOmwJ9vx8vTZzQ-WIdd-MUxp_oy3cmut854Wy4wSG4Pj0mDywOyTw5vKdks3q_Xn4oLz6ff1yeXZRYKTmV2DQSuAVhK2ptZ2SHwsq-ZZ1A1SK2qjamRUtBqv3vZYMNUt63NTOdUMBPyes5t4shpWisHqO7xbjTFPS-Hf1XO1k_m_W4bW9Nf7SHOvL-5WGPqcPB5vM7l45MCaGEpJmVM3NpMnfHNcYbLWteC73-cqXpSlSf1FehL7N_MXuLQeOPmCM3VwwoByZZXdX7xOf_CqqaCkApTlUGr2aAXdLXYRt9bvW_N_4BXOOa3w</recordid><startdate>198307</startdate><enddate>198307</enddate><creator>Towers, G. H. 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N ; Abramowski, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a496t-a88603f05f41ffce6ca5f6db2c5a9baab97eebaf1069000368a8a13db72ec5903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Alkaloids - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carex</topic><topic>Cells, Cultured</topic><topic>Chromosome Aberrations</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>DNA - analysis</topic><topic>Female</topic><topic>Furans - toxicity</topic><topic>General pharmacology</topic><topic>Genes - drug effects</topic><topic>Medical sciences</topic><topic>Ovary</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinolines - toxicity</topic><topic>RNA - analysis</topic><topic>Rutaceae</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Towers, G. H. N</creatorcontrib><creatorcontrib>Abramowski, Z</creatorcontrib><creatorcontrib>Tsentralen S"vet na Natsionalniya Agrarno-Promishlen S"yuz, Sofia (Bulgaria). Selskostopanska Akademiya. 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T"rgovsko-Promishleno Obedinenie "Bulgartabak</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UV-Mediated Genotoxicity of Furanoquinoline and of Certain Tryptophan-Derived Alkaloids</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1983-07</date><risdate>1983</risdate><volume>46</volume><issue>4</issue><spage>576</spage><epage>581</epage><pages>576-581</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and the N-methylpyrolidine substituted harmane alkaloid, brevicolline (from Carex), display phototoxicity towards bacteria and fungi in near ultraviolet light. All of these alkaloids are phototoxic to Chinese hamster ovary cells, inhibiting mitosis and causing gross chromosomal changes. The target for their phototoxicity appears to be the cell nucleus.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>6195312</pmid><doi>10.1021/np50028a027</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1983-07, Vol.46 (4), p.576-581 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Alkaloids - toxicity Animals Biological and medical sciences Carex Cells, Cultured Chromosome Aberrations Cricetinae Cricetulus DNA - analysis Female Furans - toxicity General pharmacology Genes - drug effects Medical sciences Ovary Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Quinolines - toxicity RNA - analysis Rutaceae Ultraviolet Rays - adverse effects |
| title | UV-Mediated Genotoxicity of Furanoquinoline and of Certain Tryptophan-Derived Alkaloids |
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