UV-Mediated Genotoxicity of Furanoquinoline and of Certain Tryptophan-Derived Alkaloids

Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and t...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1983-07, Vol.46 (4), p.576-581
Hauptverfasser:	Towers, G. H. N, Abramowski, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - toxicity Animals Biological and medical sciences Carex Cells, Cultured Chromosome Aberrations Cricetinae Cricetulus DNA - analysis Female Furans - toxicity General pharmacology Genes - drug effects Medical sciences Ovary Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Quinolines - toxicity RNA - analysis Rutaceae Ultraviolet Rays - adverse effects
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Beschreibung
Zusammenfassung:	Certain furanoquinolines of the Rutaceae and a number of the widely distributed beta-carboline or harmane alkaloids are photosensitizers in near ultraviolet light (320-400 nm). These compounds have been shown to be phototoxic to yeasts and bacteria. In addition, two canthinones of the Rutaceae and the N-methylpyrolidine substituted harmane alkaloid, brevicolline (from Carex), display phototoxicity towards bacteria and fungi in near ultraviolet light. All of these alkaloids are phototoxic to Chinese hamster ovary cells, inhibiting mitosis and causing gross chromosomal changes. The target for their phototoxicity appears to be the cell nucleus.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50028a027