A Constituent of Pterocarpus marsupium, (-)-Epicatechin, as a Potential Antidiabetic Agent
An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1983-03, Vol.46 (2), p.232-234 |
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| container_issue | 2 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 46 |
| creator | Sheehan, E. W Zemaitis, M. A Slatkin, D. J Schiff, P. L |
| description | An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after alloxan, there is no significant difference in blood glucose levels between control and (-)-epicatechin treated rats. These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states. |
| doi_str_mv | 10.1021/np50026a018 |
| format | Article |
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These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np50026a018</identifier><identifier>PMID: 6875579</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Benzopyrans - pharmacology ; Biological and medical sciences ; Blood Glucose - metabolism ; Catechin - pharmacology ; Diabetes Mellitus, Experimental - drug therapy ; General and cellular metabolism. Vitamins ; Hypoglycemic Agents - therapeutic use ; Male ; Medical sciences ; Pharmacology. 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These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.</description><subject>Animals</subject><subject>Benzopyrans - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Catechin - pharmacology</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MFLHDEUBvBQlHVre_Is5CCo6LQvk5lMclyWta0oXapF8BLeZDIa3Z0Zkgy0_30juyweenqQ7_fC4yPkiMEXBjn72g0lQC4QmPxApqzMIROQl3tkCkzwjEtRHJCPIbwAAAdVTshEyKosKzUljzM677sQXRxtF2nf0mW0vjfohzHQNfowDm5cX9Kz7DxbDM5gtObZdZcUA0W67GNac7iiszQah7WNztDZU3r9RPZbXAX7eTsPye-rxf38e3bz89uP-ewmw1zJmDVVK-u2wJYXpmnQoEBrKgUgAVVZiZYryRvMhTJYcFVbLlnRNCovLNi6qvkhudj8a3wfgretHrxLl__VDPRbQfpdQUkfb_Qw1mvb7Oy2kZSfbHMMBletx864sGOKg0w0sWzDXIj2zy5G_6pFxatS3y_vNHu4Vdf53S_Nkj_deDRBv_Sj71Il_z3wH8dgiR4</recordid><startdate>198303</startdate><enddate>198303</enddate><creator>Sheehan, E. W</creator><creator>Zemaitis, M. A</creator><creator>Slatkin, D. J</creator><creator>Schiff, P. 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L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a298t-d7f8bf4af34cddaca6aec790080a9576f3983da269ca439be3814dd924e0eb7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Benzopyrans - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Catechin - pharmacology</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheehan, E. W</creatorcontrib><creatorcontrib>Zemaitis, M. A</creatorcontrib><creatorcontrib>Slatkin, D. 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Prod</addtitle><date>1983-03</date><risdate>1983</risdate><volume>46</volume><issue>2</issue><spage>232</spage><epage>234</epage><pages>232-234</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after alloxan, there is no significant difference in blood glucose levels between control and (-)-epicatechin treated rats. These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>6875579</pmid><doi>10.1021/np50026a018</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1983-03, Vol.46 (2), p.232-234 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_np50026a018 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Benzopyrans - pharmacology Biological and medical sciences Blood Glucose - metabolism Catechin - pharmacology Diabetes Mellitus, Experimental - drug therapy General and cellular metabolism. Vitamins Hypoglycemic Agents - therapeutic use Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains |
| title | A Constituent of Pterocarpus marsupium, (-)-Epicatechin, as a Potential Antidiabetic Agent |
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