A Constituent of Pterocarpus marsupium, (-)-Epicatechin, as a Potential Antidiabetic Agent

An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1983-03, Vol.46 (2), p.232-234
Hauptverfasser: Sheehan, E. W, Zemaitis, M. A, Slatkin, D. J, Schiff, P. L
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Sprache:eng
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Zusammenfassung:An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after alloxan, there is no significant difference in blood glucose levels between control and (-)-epicatechin treated rats. These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50026a018