Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus
Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cyt...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.1053-1055 |
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| container_issue | 6 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 70 |
| creator | Huang, Sheng-Xiong Zhou, Yan Yang, Li-Bin Zhao, Yong Li, Sheng-Hong Lou, Li-Guang Han, Quan-Bin Ding, Li-Sheng Sun, Han-Dong |
| description | Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively. |
| doi_str_mv | 10.1021/np070086a |
| format | Article |
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Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np070086a</identifier><identifier>PMID: 17497809</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>alboatisin ; anticarcinogenic activity ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; chemical structure ; cultured cells ; cytotoxicity ; Diterpenes - chemistry ; Diterpenes - isolation & purification ; Diterpenes - pharmacology ; diterpenoids ; Drug Screening Assays, Antitumor ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - pharmacology ; General pharmacology ; Humans ; Inhibitory Concentration 50 ; Isodon ; Isodon - chemistry ; Lamiaceae ; Medical sciences ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; spectral analysis ; stereochemistry</subject><ispartof>Journal of natural products (Washington, D.C.), 2007-06, Vol.70 (6), p.1053-1055</ispartof><rights>Copyright © 2007 American Chemical Society and American Society of Pharmacognosy</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a405t-27e52d43a39f0634d39c070282bb1d2db666e6ff44a045300393e8bb7de55df73</citedby><cites>FETCH-LOGICAL-a405t-27e52d43a39f0634d39c070282bb1d2db666e6ff44a045300393e8bb7de55df73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np070086a$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np070086a$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18902807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17497809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Sheng-Xiong</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Yang, Li-Bin</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Li, Sheng-Hong</creatorcontrib><creatorcontrib>Lou, Li-Guang</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Ding, Li-Sheng</creatorcontrib><creatorcontrib>Sun, Han-Dong</creatorcontrib><title>Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.</description><subject>alboatisin</subject><subject>anticarcinogenic activity</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>cultured cells</subject><subject>cytotoxicity</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - isolation & purification</subject><subject>Diterpenes - pharmacology</subject><subject>diterpenoids</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Isodon</subject><subject>Isodon - chemistry</subject><subject>Lamiaceae</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>spectral analysis</subject><subject>stereochemistry</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLtOxDAQRS0EguVR8AOQhgKJwNiO7bhclqcEAsSjoLGc2EaB3TiysxL8ATWfyJdgtCugoBpp5szMvRehTQz7GAg-aDsQACXXC2iAGYGcA2GLaACY05yWvFhBqzE-AwAFyZbRChaFFCXIARoNx5XXfRObNmbDz_eP0V5m2z4fppZtbXbU9DZ0tvWNiZkLfpKdR298m-m01zVjH6dxHS05PY52Y17X0P3J8d3oLL-4Oj0fDS9yXQDrcyIsI6agmkoHnBaGyjrpJiWpKmyIqTjnljtXFBoKRpNYSW1ZVcJYxowTdA3tzu7WwccYrFNdaCY6vCkM6jsI9RNEYrdmbDetJtb8knPnCdiZAzrWeuyCbusm_nKlTMrg-2k-45rY29efuQ4vigsqmLq7vlUP7JDewOWjekj89ox32iv9FNLN-1sCOPkRUgr857Ouo3r209Cm0P6x8AX8RImk</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Huang, Sheng-Xiong</creator><creator>Zhou, Yan</creator><creator>Yang, Li-Bin</creator><creator>Zhao, Yong</creator><creator>Li, Sheng-Hong</creator><creator>Lou, Li-Guang</creator><creator>Han, Quan-Bin</creator><creator>Ding, Li-Sheng</creator><creator>Sun, Han-Dong</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20070601</creationdate><title>Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus</title><author>Huang, Sheng-Xiong ; Zhou, Yan ; Yang, Li-Bin ; Zhao, Yong ; Li, Sheng-Hong ; Lou, Li-Guang ; Han, Quan-Bin ; Ding, Li-Sheng ; Sun, Han-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a405t-27e52d43a39f0634d39c070282bb1d2db666e6ff44a045300393e8bb7de55df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>alboatisin</topic><topic>anticarcinogenic activity</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>cultured cells</topic><topic>cytotoxicity</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - pharmacology</topic><topic>diterpenoids</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Isodon</topic><topic>Isodon - chemistry</topic><topic>Lamiaceae</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>spectral analysis</topic><topic>stereochemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Sheng-Xiong</creatorcontrib><creatorcontrib>Zhou, Yan</creatorcontrib><creatorcontrib>Yang, Li-Bin</creatorcontrib><creatorcontrib>Zhao, Yong</creatorcontrib><creatorcontrib>Li, Sheng-Hong</creatorcontrib><creatorcontrib>Lou, Li-Guang</creatorcontrib><creatorcontrib>Han, Quan-Bin</creatorcontrib><creatorcontrib>Ding, Li-Sheng</creatorcontrib><creatorcontrib>Sun, Han-Dong</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Sheng-Xiong</au><au>Zhou, Yan</au><au>Yang, Li-Bin</au><au>Zhao, Yong</au><au>Li, Sheng-Hong</au><au>Lou, Li-Guang</au><au>Han, Quan-Bin</au><au>Ding, Li-Sheng</au><au>Sun, Han-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>70</volume><issue>6</issue><spage>1053</spage><epage>1055</epage><pages>1053-1055</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>17497809</pmid><doi>10.1021/np070086a</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | alboatisin anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences chemical structure cultured cells cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology General pharmacology Humans Inhibitory Concentration 50 Isodon Isodon - chemistry Lamiaceae Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry spectral analysis stereochemistry |
| title | Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus |
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