Alboatisins A−C, ent-Atisene Diterpenoids from Isodon albopilosus

Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cyt...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.1053-1055
Hauptverfasser:	Huang, Sheng-Xiong, Zhou, Yan, Yang, Li-Bin, Zhao, Yong, Li, Sheng-Hong, Lou, Li-Guang, Han, Quan-Bin, Ding, Li-Sheng, Sun, Han-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	alboatisin anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences chemical structure cultured cells cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology General pharmacology Humans Inhibitory Concentration 50 Isodon Isodon - chemistry Lamiaceae Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry spectral analysis stereochemistry
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Zusammenfassung:	Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A−C (1−3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np070086a