Aegicerin, the First Oleanane Triterpene with Wide-Ranging Antimycobacterial Activity, Isolated from Clavija p rocera

Aegicerin, the First Oleanane Triterpene with Wide-Ranging Antimycobacterial Activity, Isolated from Clavija p rocera

An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2006-05, Vol.69 (5), p.845-846
Hauptverfasser: Rojas, Rosario, Caviedes, Luz, Aponte, José C, Vaisberg, Abraham J, Lewis, Walter H, Lamas, Gerardo, Sarasara, César, Gilman, Robert H, Hammond, Gerald B
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 μg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
ISSN:0163-3864
1520-6025
DOI:10.1021/np050554l