Hemisynthetic Secofriedelane Triterpenes with Inhibitory Activity against the Growth of Human Tumor Cell Lines in Vitro

Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5−9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-sma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-07, Vol.67 (7), p.1193-1196
Hauptverfasser:	Moiteiro, Cristina, Manta, César, Justino, Fátima, Tavares, Regina, Curto, Maria João M, Pedro, Madalena, Nascimento, Maria São José, Pinto, Madalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General aspects Humans Inhibitory Concentration 50 Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacology. Drug treatments Structure-Activity Relationship Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!