Hemisynthetic Secofriedelane Triterpenes with Inhibitory Activity against the Growth of Human Tumor Cell Lines in Vitro

Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5−9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-sma...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-07, Vol.67 (7), p.1193-1196
Hauptverfasser:	Moiteiro, Cristina, Manta, César, Justino, Fátima, Tavares, Regina, Curto, Maria João M, Pedro, Madalena, Nascimento, Maria São José, Pinto, Madalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General aspects Humans Inhibitory Concentration 50 Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacology. Drug treatments Structure-Activity Relationship Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5−9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI50 values that range from 24.6 to 32.8 μM and 10.9 to 17.6 μM, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0498915