Grayanane Diterpenoids from the Flowers of Rhododendron molle with Cytotoxic Activity against a Spodoptera frugiperda Cell Line

Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-06, Vol.68 (6), p.924-926
Hauptverfasser:	Zhong, Guohua, Hu, Meiying, Wei, Xiaoyi, Weng, Qunfang, Xie, Jianjun, Liu, Jingxiang, Wang, Wenxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Chemical control chemical structure China Control cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor Flowers - chemistry Fundamental and applied biological sciences. Psychology General pharmacology grayanane Inhibitory Concentration 50 Medical sciences medicinal plants Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytopathology. Animal pests. Plant and forest protection plant extracts Plants, Medicinal - chemistry Protozoa. Invertebrates Rhododendron Rhododendron - chemistry Rhododendron molle rhodojaponin rhodomolins rhodomolleins spectral analysis Spodoptera - cytology Spodoptera - drug effects Spodoptera frugiperda
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Beschreibung
Zusammenfassung:	Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds were evaluated for cytotoxic activity against the Spodoptera frugiperda cell line Sf-9 and gave IC50 values in the range 12−80 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049645t