Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma n odosum

Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma n odosum

The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubul...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.475-478
Hauptverfasser: Schmidt, Eric W, Raventos-Suarez, Carmen, Bifano, Marc, Menendez, Ana T, Fairchild, Craig R, Faulkner, D. John
Format: Artikel
Sprache:eng
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Zusammenfassung:The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np034035z