Lactones from the Leaves of Litsea j aponica and Their Anti-complement Activity

Lactones from the Leaves of Litsea j aponica and Their Anti-complement Activity

Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activ...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2003-10, Vol.66 (10), p.1388-1390
Hauptverfasser: Min, Byung Sun, Lee, Sun Young, Kim, Jung Hee, Kwon, Ok Kyoung, Park, Bo Young, An, Ren Bo, Lee, Joong Ku, Moon, Hyung In, Kim, Tae Jin, Kim, Young Ho, Joung, Hyouk, Lee, Hyeong Kyu
Format: Artikel
Sprache:eng
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Zusammenfassung:Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC50 values of 149 and 58 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030227i