Reaction of Irofulven with Zinc and Acid

Reaction of Irofulven with Zinc and Acid

Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2003-02, Vol.66 (2), p.310-312
Hauptverfasser: McMorris, Trevor C, Moon, Surk-Sik, Kelner, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Acetic Acid - chemistry
Antineoplastic agents
Antineoplastic Agents, Alkylating - chemistry
Antineoplastic Agents, Alkylating - pharmacology
Biological and medical sciences
Chromatography, Thin Layer
Drug Screening Assays, Antitumor
General aspects
HL-60 Cells - drug effects
Humans
Indenes - chemistry
Indicators and Reagents
Inhibitory Concentration 50
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacology. Drug treatments
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Zinc - chemistry
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Zusammenfassung:Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0204085