Chemical Constituents of Calophyllum brasiliense. 2. Structure of Three New Coumarins and Cancer Chemopreventive Activity of 4-Substituted Coumarins

Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-03, Vol.66 (3), p.368-371
Hauptverfasser:	Ito, Chihiro, Itoigawa, Masataka, Mishina, Yoshitaka, Filho, Valdir Cechinel, Enjo, Fumio, Tokuda, Harukuni, Nishino, Hoyoku, Furukawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Anticarcinogenic Agents - chemistry Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology Antigens, Viral - drug effects antineoplastic agents bark Biological and medical sciences brasimarins Brazil calanolides Calophyllum Calophyllum - chemistry Calophyllum brasiliense cell lines Cells, Cultured - drug effects chemical structure chemoprevention coumarins Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Drug Screening Assays, Antitumor General pharmacology Human herpesvirus 4 Humans inophyllums Lymphoma, B-Cell Medical sciences Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenylcoumarin phytochemicals Plant Bark - chemistry plant extracts Plants, Medicinal - chemistry propylcoumarin spectral analysis stems Tetradecanoylphorbol Acetate - pharmacology
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Zusammenfassung:	Continuing our search for cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these coumarins on Epstein−Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0203640