14‘-Hydroxymytoxin B and 16-Hydroxyroridin E, Two New Cytotoxic Trichothecenes from Myrothecium roridum

Two new trichothecenes, 14‘-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarco...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-05, Vol.65 (5), p.742-744
Hauptverfasser:	Alvi, Khisal A, Rabenstein, John, Woodard, Jon, Baker, Dwight D, Bergthold, Jennifer D, Lynch, John, Lieu, Kuo L, Braude, Irwin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Applied microbiology Biological and medical sciences Boston Cells, Cultured - drug effects Chemotherapic agents Chromatography, High Pressure Liquid Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Fungi - chemistry Humans Inhibitory Concentration 50 Microbiology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sarcoma Trichothecenes - chemistry Trichothecenes - isolation & purification Trichothecenes - pharmacology Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Two new trichothecenes, 14‘-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010449l