A New Dimeric Stilbene with Tyrosinase Inhibitiory Activity From Artocarpus gomezianus

A new dimeric stilbene, namely, artogomezianol (1), and the known compound andalasin A (2) were isolated from the roots of Artocarpus gomezianus. Both 1 and 2 showed moderate tyrosinase inhibitory activity with IC50 values of 68 and 39 μM, respectively.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-11, Vol.64 (11), p.1457-1459
Hauptverfasser:	Likhitwitayawuid, Kittisak, Sritularak, Boonchoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology Inhibitory Concentration 50 Medical sciences Molecular Conformation Molecular Structure Monophenol Monooxygenase - antagonists & inhibitors Moraceae - chemistry Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology Structure-Activity Relationship Thailand
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Beschreibung
Zusammenfassung:	A new dimeric stilbene, namely, artogomezianol (1), and the known compound andalasin A (2) were isolated from the roots of Artocarpus gomezianus. Both 1 and 2 showed moderate tyrosinase inhibitory activity with IC50 values of 68 and 39 μM, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0101806