Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis

Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis

An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one new rhamnosylanthraquinone, 3‘-O-acetylfrangulin A (8), several new rhamnosyl...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2001-09, Vol.64 (9), p.1162-1168
Hauptverfasser: Mai, Le Phuong, Guéritte, Françoise, Dumontet, Vincent, Tri, Mai Van, Hill, Bridget, Thoison, Odile, Guénard, Daniel, Sévenet, Thierry
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anthraquinones - chemistry
Anthraquinones - isolation & purification
Anthraquinones - pharmacology
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Drug Screening Assays, Antitumor
Fruit - chemistry
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
KB Cells
Leukemia - chemically induced
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred Strains
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
Plants, Medicinal - chemistry
Rhamnaceae - chemistry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Stereoisomerism
Structure-Activity Relationship
Tumor Cells, Cultured - drug effects
Vietnam
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Zusammenfassung:An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one new rhamnosylanthraquinone, 3‘-O-acetylfrangulin A (8), several new rhamnosylanthrones, the prinoidin-emodin bianthrones (9A−D), the prinoidin bianthrones (10A,B), and the rhamnepalins (11A−C). A structure−cytotoxic activity relationship study was performed on these isolates and some semisynthetic derivatives.
ISSN:0163-3864
1520-6025
DOI:10.1021/np010030v