Steroidal Alkaloids from the Leaves of Sarcococca c oriacea of Nepalese Origin

Steroidal Alkaloids from the Leaves of Sarcococca c oriacea of Nepalese Origin

Two new steroidal alkaloids, (−)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3β-(senecioylamino)-5α-pregn-16-en-4β-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3β-(tigloylamino)-5α-pregn-16-en-2β,4β-diacetate], were isolated from the leaves of Sarcococca coriacea. Their stru...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2001-06, Vol.64 (6), p.842-844
Hauptverfasser: Kalauni, Surya K, Choudhary, M. Iqbal, Shaheen, Farzana, Manandhar, Mangala D, Atta-ur-Rahman, Gewali, Mohan B, Khalid, Asaad
Format: Artikel
Sprache:eng
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Zusammenfassung:Two new steroidal alkaloids, (−)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3β-(senecioylamino)-5α-pregn-16-en-4β-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3β-(tigloylamino)-5α-pregn-16-en-2β,4β-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000466v