Cancer Chemopreventive Agents. New Depsidones from Garcinia Plants

In a search for cancer chemopreventive agents from natural sources, chemical constituents of two kinds of Garcinia plants, Garcinia neglecta and Garcinia puat, collected in New Caledonia, were examined. Five new depsidones, garcinisidone-B (2), -C (3), -D (4), -E (5), and -F (6), were isolated, and...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-02, Vol.64 (2), p.147-150
Hauptverfasser:	Ito, Chihiro, Itoigawa, Masataka, Mishina, Yoshitaka, Tomiyasu, Hiromi, Litaudon, Marc, Cosson, Jean-Pierre, Mukainaka, Teruo, Tokuda, Harukuni, Nishino, Hoyoku, Furukawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents Antigens, Viral - metabolism Biological and medical sciences Ericales - chemistry Ethers, Cyclic - chemistry Ethers, Cyclic - isolation & purification Ethers, Cyclic - pharmacology General pharmacology Herpesvirus 4, Human - drug effects Humans Medical sciences Models, Chemical New Caledonia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured
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Zusammenfassung:	In a search for cancer chemopreventive agents from natural sources, chemical constituents of two kinds of Garcinia plants, Garcinia neglecta and Garcinia puat, collected in New Caledonia, were examined. Five new depsidones, garcinisidone-B (2), -C (3), -D (4), -E (5), and -F (6), were isolated, and their structures were determined by spectrometric analyses. Inhibitory effects of these depsidones on EBV-EA activation induced by TPA in Raji cells were also demonstrated.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000333+