Cellular Toxicity of Carbon-Based Nanomaterials

The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro on lung tumor cells. Our work clearly indicat...

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Veröffentlicht in:	Nano letters 2006-06, Vol.6 (6), p.1121-1125
Hauptverfasser:	Magrez, Arnaud, Kasas, Sandor, Salicio, Valérie, Pasquier, Nathalie, Seo, Jin Won, Celio, Marco, Catsicas, Stefan, Schwaller, Beat, Forró, László
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cross-disciplinary physics: materials science rheology Dose-Response Relationship, Drug Exact sciences and technology Humans Lung Neoplasms - pathology Materials science Nanoscale materials and structures: fabrication and characterization Nanotubes Nanotubes, Carbon - chemistry Nanotubes, Carbon - toxicity Nanotubes, Carbon - ultrastructure Other topics in nanoscale materials and structures Physics Surface Properties
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Zusammenfassung:	The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro on lung tumor cells. Our work clearly indicated that these materials are toxic while the hazardous effect is size-dependent. Moreover, cytotoxicity is enhanced when the surface of the particles is functionalized after an acid treatment.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl060162e