Isolation and Characterization of Trioxyethylene-Encapsulated Gold Nanoclusters Functionalized with a Single DNA Strand

A scalable means of isolating significant quantities of trioxyethylene-encapsulated gold nanoclusters (GNCs) labeled with a single DNA strand is demonstrated. Quantitative characterization of the product is obtained using UV−vis absorbance spectroscopy. These methods of isolation and characterizatio...

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Veröffentlicht in:Nano letters 2004-04, Vol.4 (4), p.737-740
Hauptverfasser: Jhaveri, Sulay D, Foos, Edward E, Lowy, Daniel A, Chang, Eddie L, Snow, Arthur W, Ancona, Mario G
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Sprache:eng
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Zusammenfassung:A scalable means of isolating significant quantities of trioxyethylene-encapsulated gold nanoclusters (GNCs) labeled with a single DNA strand is demonstrated. Quantitative characterization of the product is obtained using UV−vis absorbance spectroscopy. These methods of isolation and characterization of singly functionalized GNC−ssDNA conjugates are expected to aid development of nanoscience applications that use DNA molecular recognition for guiding self-assembly.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl0499591