The Many Faces of Gold Nanorods

Gold nanorods exhibit optical properties that are tunable with their shape, leading to sensing, imaging, and biomedical therapeutic applications. Colloidal preparations of gold nanorods impart surfactants or other species on the nanorod surfaces; a popular preparation leads to a surfactant bilayer on the surface. The specific chemistry at three distinct interfaces has roles to play in the growth and subsequent usage of these nanomaterials; these interfaces are the gold−surfactant interface, the hydrophobic surfactant bilayer, and, finally, the surfactant interface with the aqueous bulk. Each one of these interfaces provides strategies for altering nanorod properties such as stability against aggregation, toxicity, and ease of assembly. It is the solvent-accessible interface that dictates nanorod interactions with other particles, macromolecules, and living cells.