Predicting Solubilities in Supercritical Fluids

We present a simple treatment of supercritical fluid extraction, including entrainer effects. Solubility predictions are made using the Redlich−Kwong equation of state: parameters for this equation are calculated directly from intermolecular potentials. We have tested our approach in the low-solubility limit by comparing with computer simulations. Good agreement is found for realistic values of the potential parameters describing solute−solvent and solvent−solvent interactions.