Protein Folding Dynamics:  Application of the Diffusion-Collision Model to the Folding of a Four-Helix Bundle

A de novo designed four-helix bundle polypeptide with a modeled three-dimensional structure has been studied by chemical kinetics and Brownian dynamics simulations as an application of the diffusion−collision model. The complementary studies give information on kinetic pathways in the folding of the peptide and on the statistical propensities and time histories of the positions and orientations of the four helices.