Concentration Profiles of Individual Species in Coupled Binding of Two Ligands by a Receptor

Equations for the concentration profiles of all species in equilibria in the coupled binding of two ligands to a receptor have been formulated in a compact translucent form convenient for numerical analyses. These have been used to generate graphical presentations of the variation of each profile ov...

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Veröffentlicht in:The journal of physical chemistry. B 2003-10, Vol.107 (39), p.10887-10893
Hauptverfasser: Dunietz, Isard, Klotz, Irving M, Walder, Joseph A
Format: Artikel
Sprache:eng
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Zusammenfassung:Equations for the concentration profiles of all species in equilibria in the coupled binding of two ligands to a receptor have been formulated in a compact translucent form convenient for numerical analyses. These have been used to generate graphical presentations of the variation of each profile over a wide range of ligand concentration. New insights into the distribution of species have been obtained.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp030203k