An Extremely Powerful Acylation Reaction of Alcohols with Acid Anhydrides Catalyzed by Trimethylsilyl Trifluoromethanesulfonate

An Extremely Powerful Acylation Reaction of Alcohols with Acid Anhydrides Catalyzed by Trimethylsilyl Trifluoromethanesulfonate

Trimethylsilyl trifluoromethanesulfonate is an excellent catalyst for the acylation of alcohols with acid anhydrides. Highly functionalized primary, secondary, tertiary, and allylic alcohols, and phenols, were acylated cleanly and efficiently and in a fraction of the time used under the standard DMA...

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Veröffentlicht in:Journal of organic chemistry 1998-04, Vol.63 (7), p.2342-2347
Hauptverfasser: Procopiou, Panayiotis A., Baugh, Simon P. D., Flack, Stephen S., Inglis, Graham G. A.
Format: Artikel
Sprache:eng
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Zusammenfassung:Trimethylsilyl trifluoromethanesulfonate is an excellent catalyst for the acylation of alcohols with acid anhydrides. Highly functionalized primary, secondary, tertiary, and allylic alcohols, and phenols, were acylated cleanly and efficiently and in a fraction of the time used under the standard DMAP conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo980011z