Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists

Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists

An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry...

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Veröffentlicht in:Journal of organic chemistry 2003-04, Vol.68 (7), p.2623-2632
Hauptverfasser: Godfrey, Alexander G, Brooks, Dawn A, Hay, Lynne A, Peters, Mary, McCarthy, James R, Mitchell, David
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Sprache:eng
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Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Organic chemistry
Preparations and properties
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container_end_page 2632
container_issue 7
container_start_page 2623
container_title Journal of organic chemistry
container_volume 68
creator Godfrey, Alexander G
Brooks, Dawn A
Hay, Lynne A
Peters, Mary
McCarthy, James R
Mitchell, David
description An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.
doi_str_mv 10.1021/jo026655v
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source American Chemical Society Journals
subjects Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Organic chemistry
Preparations and properties
title Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists
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