Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists

An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry...

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Veröffentlicht in:	Journal of organic chemistry 2003-04, Vol.68 (7), p.2623-2632
Hauptverfasser:	Godfrey, Alexander G, Brooks, Dawn A, Hay, Lynne A, Peters, Mary, McCarthy, James R, Mitchell, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin−West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo026655v