Direct Preparation of N-Quaternized and N-Oxidized Polycyclic Azines by Palladium-Catalyzed Cross-Coupling. An Unequivocal Isomer Synthesis

Direct Preparation of N-Quaternized and N-Oxidized Polycyclic Azines by Palladium-Catalyzed Cross-Coupling. An Unequivocal Isomer Synthesis

The authors report several examples of unequivocal isomer preparations using palladium-catalyzed cross-coupling to yield N-oxides and N-quaternized polycyclic azines. This approach serves as a model for such syntheses where selective N-quaternization, N-oxidation, or other types of N-functionalizati...

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Veröffentlicht in:Journal of Organic Chemistry 1995-01, Vol.60 (1), p.264-267
Hauptverfasser: Zoltewicz, John A, Cruskie, Michael P. Jr, Dill, Carlton D
Format: Artikel
Sprache:eng
Schlagworte:
40 CHEMISTRY
CATALYTIC EFFECTS
CHEMICAL PREPARATION
ORGANIC NITROGEN COMPOUNDS
PALLADIUM COMPLEXES
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Zusammenfassung:The authors report several examples of unequivocal isomer preparations using palladium-catalyzed cross-coupling to yield N-oxides and N-quaternized polycyclic azines. This approach serves as a model for such syntheses where selective N-quaternization, N-oxidation, or other types of N-functionalization of several rings is now possible in a regioncontrolled manner.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00106a047