Discovery of 1-(2,4-Dichlorophenyl)- N -(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1 H -pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

Discovery of 1-(2,4-Dichlorophenyl)- N -(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1 H -pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

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Veröffentlicht in:Journal of medicinal chemistry 2013-12, Vol.56 (24), p.9920-9933
Hauptverfasser: Chang, Chun-Ping, Wu, Chien-Huang, Song, Jen-Shin, Chou, Ming-Chen, Wong, Ying-Chieh, Lin, Yinchiu, Yeh, Teng-Kuang, Sadani, Amit A., Ou, Ming-Hung, Chen, Kun-Hung, Chen, Pei-Hsuan, Kuo, Po-Chu, Tseng, Chen-Tso, Chang, Kuei-Hua, Tseng, Shi-Liang, Chao, Yu-Sheng, Hung, Ming-Shiu, Shia, Kak-Shan
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Sprache:eng
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm401158e