In Vitro Cytotoxic Activities of 2-Alkyl-4,6-diheteroalkyl-1,3,5-triazines: New Molecules in Anticancer Research

The cytotoxic activities of new 2-alkyl-4,6-dihetero(N,O)alkyl-1,3,5-triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2004-09, Vol.47 (19), p.4649-4652
Hauptverfasser:	Menicagli, Rita, Samaritani, Simona, Signore, Giovanni, Vaglini, Francesca, Dalla Via, Lisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Biological and medical sciences Biomedical Research Cell Death - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor General aspects Humans Inhibitory Concentration 50 Medical sciences Miscellaneous Molecular Structure Neoplasms - drug therapy Neoplasms - pathology Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The cytotoxic activities of new 2-alkyl-4,6-dihetero(N,O)alkyl-1,3,5-triazines toward selected tumor cell lines have been evaluated, and for the first time, the potential of 2-alkyl-4,6-dialkoxy-1,3,5-triazines has been shown.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm0495374