Design, Synthesis, and Evaluation of Novel Boronic-Chalcone Derivatives as Antitumor Agents

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2003-07, Vol.46 (14), p.2813-2815
Hauptverfasser:	Kumar, Srinivas K, Hager, Erin, Pettit, Catherine, Gurulingappa, Hallur, Davidson, Nancy E, Khan, Saeed R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Biological and medical sciences Boron Compounds - chemical synthesis Boron Compounds - pharmacology Cell Division - drug effects Chalcone - analogs & derivatives Chalcone - chemical synthesis Chalcone - pharmacology Drug Screening Assays, Antitumor General aspects Humans Medical sciences Nuclear Proteins Pharmacology. Drug treatments Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-mdm2 Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm030213+