Some biological properties of the impure dichloride salt of tetrakis[p-(dimethylamino)phenyl]ethylene and a pinacolone

The impure dichloride salt of tetrakis[p-(dimethylamino)phenyl]ethylene and a pinacolone that is a substituted acetophenone show several biological properties, one of which is activity against lymphosarcoma in mice. The involvement, if any, of free radicals in the biological properties of these subs...

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Veröffentlicht in:	Journal of medicinal chemistry 1983-11, Vol.26 (11), p.1645-1647
Hauptverfasser:	LePage, Gerald A, Elofson, Richard M, Schulz, Karlo F, Laidler, James, Kowalewski, Konstanty P, Hay, Allan S, Crawford, Robert J, Tanner, Dennis, Sandin, Reuben B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - isolation & purification Acetophenones - toxicity Aniline Compounds - isolation & purification Aniline Compounds - toxicity Animals Biological and medical sciences Carcinoma 256, Walker - drug therapy Carcinoma 256, Walker - physiopathology Drug Evaluation, Preclinical Electron Spin Resonance Spectroscopy General pharmacology Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships
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Zusammenfassung:	The impure dichloride salt of tetrakis[p-(dimethylamino)phenyl]ethylene and a pinacolone that is a substituted acetophenone show several biological properties, one of which is activity against lymphosarcoma in mice. The involvement, if any, of free radicals in the biological properties of these substances is discussed.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00365a018