5-Aryl-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ols. Novel class of anorectic agents

A series of 5-aryl-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ols (IV), prepared by the LiA1H4 reduction of the corresponding 9b-aryl-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones (II), was evaluated for suppression of food consumption in rats. One member of this series, 5-p-chlorophenyl-2,3-dih...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-02, Vol.18 (2), p.177-182
Hauptverfasser:	Aeberli, Paul, Eden, Phillip, Gogerty, John H, Houlihan, William J, Penberthy, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite - drug effects Appetite Depressants - chemical synthesis Appetite Depressants - pharmacology Appetite Depressants - toxicity Behavior, Animal - drug effects Depression, Chemical Feeding Behavior - drug effects Haplorhini Imidazoles - chemical synthesis Imidazoles - pharmacology Imidazoles - toxicity Indoles - chemical synthesis Indoles - pharmacology Indoles - toxicity Lethal Dose 50 Male Rats Spectrophotometry, Ultraviolet
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Zusammenfassung:	A series of 5-aryl-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ols (IV), prepared by the LiA1H4 reduction of the corresponding 9b-aryl-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones (II), was evaluated for suppression of food consumption in rats. One member of this series, 5-p-chlorophenyl-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol (6, mazindol), was evaluated in squirrel and capuchin monkeys and found to have anorexic activity approximately equal to d-amphetamine.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00236a014