Nitrones. 7. .alpha.-Quinoxalinyl-N-substituted nitrone 1,4-dioxides

A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active a...

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Veröffentlicht in:	Journal of medicinal chemistry 1977-04, Vol.20 (4), p.557-560
Hauptverfasser:	Kim, Hyun K, Miller, Laird F, Bambury, Ronald E, Ritter, Harry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - therapeutic use Antiprotozoal Agents - chemical synthesis Bacteria - drug effects Lethal Dose 50 Methods Mice Protozoan Infections - drug therapy Quinoxalines - chemical synthesis Quinoxalines - pharmacology Quinoxalines - toxicity Structure-Activity Relationship Turkeys
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Beschreibung
Zusammenfassung:	A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00214a019