3-Aminotetrahydrocarbazoles as a new series of central nervous system agents

3-Dimethylamino-1,2,3,4-tetrahydrocarbazole, a structurally modified tryptamine, prevented amphetamine-induced stereotyped behavior in rats and prevented reserpine-induced ptosis in mice. Further study of this compound and a number of substituted derivatives indicated that either imipramine-like or...

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Veröffentlicht in:	Journal of medicinal chemistry 1977-04, Vol.20 (4), p.487-492
Hauptverfasser:	Mooradian, Aram, Dupont, Paul E, Hlavac, Allan G, Aceto, Mario D, Pearl, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - antagonists & inhibitors Animals Apomorphine - pharmacology Blepharoptosis - chemically induced Blepharoptosis - prevention & control Carbazoles - chemical synthesis Carbazoles - pharmacology Central Nervous System - drug effects Haplorhini Humans Macaca mulatta Male Mice Rats Reserpine - antagonists & inhibitors Stereotyped Behavior - drug effects Structure-Activity Relationship Vomiting - chemically induced Vomiting - prevention & control
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Beschreibung
Zusammenfassung:	3-Dimethylamino-1,2,3,4-tetrahydrocarbazole, a structurally modified tryptamine, prevented amphetamine-induced stereotyped behavior in rats and prevented reserpine-induced ptosis in mice. Further study of this compound and a number of substituted derivatives indicated that either imipramine-like or chlorpromazine-like profiles were obtainable by changing substituents and their positions.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00214a005