Synthesis of steroidal nitrosoureas with antitumor activity

Four steroidal nitrosoureas with structures which may permit specific binding to estrogen receptor were synthesized. Inhibitory activity was observed against the growth of the DMBA-induced transplantable rat mammary tumor 13762.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1979-02, Vol.22 (2), p.200-202
Hauptverfasser:	Lam, Hing-Yat P, Begleiter, Asher, Goldenberg, Gerald J, Wong, Chiu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Adenocarcinoma - chemically induced Adenocarcinoma - drug therapy Animals Antineoplastic Agents - chemical synthesis Estradiol - analogs & derivatives Estradiol - chemical synthesis Estradiol - pharmacology Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - drug therapy Neoplasm Transplantation Nitrosourea Compounds - chemical synthesis Nitrosourea Compounds - pharmacology Rats Rats, Inbred F344
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Beschreibung
Zusammenfassung:	Four steroidal nitrosoureas with structures which may permit specific binding to estrogen receptor were synthesized. Inhibitory activity was observed against the growth of the DMBA-induced transplantable rat mammary tumor 13762.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00188a015