Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator

Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator

A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.

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Veröffentlicht in:Journal of medicinal chemistry 1980-10, Vol.23 (10), p.1130-1133
Hauptverfasser: Bergeron, Raymond J, Burton, Philip S, McGovern, Kathy Ann, St. Onge, Erica J, Streiff, Richard R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
In Vitro Techniques
Intestinal Absorption
Iron Chelating Agents - chemical synthesis
Iron Chelating Agents - metabolism
Iron Chelating Agents - toxicity
Mice
Spermidine - analogs & derivatives
Spermidine - chemical synthesis
Spermidine - metabolism
Spermidine - toxicity
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Zusammenfassung:A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00184a013