Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser 42 -Phe-Leu-Leu-Arg 46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups:  Importance of a Phe/Arg/NH 2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics

Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser 42 -Phe-Leu-Leu-Arg 46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups:  Importance of a Phe/Arg/NH 2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of medicinal chemistry 2001-02, Vol.44 (3), p.328-339
Hauptverfasser: Alexopoulos, Kostas, Panagiotopoulos, Dimitris, Mavromoustakos, Thomas, Fatseas, Panagiotis, Paredes-Carbajal, Maria Christina, Mascher, Dieter, Mihailescu, Stefan, Matsoukas, John
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:
ISSN:0022-2623
1520-4804
DOI:10.1021/jm0001525