Mosquitocidal Compounds and a Triglyceride, 1,3-Dilinoleneoyl-2-palmitin, from Ocimum sanctum

The hexane extract of Ocimum sanctum was investigated using mosquito bioassay guided fractionation and yielded compounds 1 and 2. The isolation of the triglyceride, 1, 3-dilinoleneoyl-2-palmitin (3) from O. sanctum leaves and stems is novel. The structures of these compounds were established using 1H and 13C NMR spectral data. Compounds eugenol (1) and (E)-6-hydroxy-4,6-dimethyl-3-heptene-2-one (2) demonstrated mosquitocidal activity at 200 and 6.25 μg mL-1 in 24 h, respectively, on fourth-instar Aedes aegyptii larvae. Keywords: Ocimum sanctum; Lamiaceae; sacred basil; 1,3-dilinoleneoyl-2-palmitin; eugenol; (E)-6-hydroxy-4,6-dimethyl-3-heptene-2-one; mosquitocidal